Tokyo stocks fell 0.69% today on nervousness over the international response to alleged chemical weapon use in Syria.
The Nikkei 225 index closed 93.91 points lower at 13,542.37, while the Topix index of all first-section issues fell 0.52%, or 5.98 points, to 1,134.02.
"Longer-term investors see a whole host of broader political and macroeconomic factors - including rising tensions over Syria, US Fed tapering worries, German elections, Greek bailout chatter - as too powerful to encourage meaningful investment in equities at the moment," said an equity trading director at a foreign brokerage.
"The wait-and-see approach is seen as safest right now," the broker told Dow Jones Newswires.
CLSA equity strategist Nicholas Smith said: "Military conflicts in the Middle East tend to lift energy prices, but Syria is a bit different in that the nation has little oil and only a marginal economic impact, so the impact on global markets may be limited."
Among major shares, Toyota dropped 0.81% to 6,160 yen (RM209.12). Mobile carrier SoftBank fell 0.48% to 6,240 yen.
With the Ebola outbreak swiftly spreading in West Africa, Tokyo Metropolitan Bokutoh Hospital opened to the press on Wednesday a special isolation ward for highly dangerous infectious diseases. (The Japan News)
The operator of the Fukushima Daiichi nuclear power plant has begun dismantling the cover of a reactor building to remove debris as part of preparations for removing the nuclear fuel from a spent fuel storage pool. (NHK)
In possibly a legal first, a female civil servant on Tuesday sued the government over what she calls institutional sexism at the ministry she works for, citing almost two decades of blocked promotions and pay raises. (Japan Times)
Osaka Prefectural Police on Friday arrested two male suspects for allegedly dumping a large quantity of adult video (AV) material inside a park in Nishinari Ward, reports the Sankei Shimbun (Oct. 17). (Tokyo Reporter)